Vascularisation of Electrospun Nanomatrices in vivo

نویسندگان

  • Dorothee Klumpp
  • Andreas Hess
  • Franz F. Bitto
  • Anja M. Boos
  • Ulrich Kneser
  • Raymund E. Horch
  • Justus P. Beier
  • Hans Georg Geis
چکیده

Introduction The clinical application of nanotechnology and nanofiber scaffolds especially has been boosted in the last years. Until now no data exist regarding the vascularisation of such electrospun nanofiber scaffolds in vivo, especially not on the necessary duration of prevascularisation which would then mark the best time point for secondary cell implantation. Since this period of vascularisation is essential for successful Tissue Engineering approaches in vivo, the aim of this study was the assessment of in vivo vascularisation phenomena within different, newly developed electrospun nanofibers in the microsurgical AV-loop rat model.

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تاریخ انتشار 2010